Micky van de Ven Brace Ends Everton's Unbeaten Streak at New Stadium
The Dutch defender became the initial defender to score twice in a English top-flight match for Tottenham since Jan Vertonghen in spring 2013.
Match summary
The Spurs defender nods home two times in opening period
Everton's Jake O'Brien has equalizer ruled after video check
Pape Matar Sarr scores third in dying moments
The defeat is the Merseyside club's initial at their new ground
The Tottenham defender scored on two occasions as Tottenham prolonged their winning streak in away games in the top division and delivered Everton their initial loss at Hill Dickinson Stadium.
The Toffees were unbeaten in their last five matches at their recently opened stadium at the dockside location, having departed their historic home behind after 133 years at the end of last season.
But Tottenham's leader the Dutchman pounced twice from set-pieces in the opening 45 minutes to place their strong form at jeopardy, and they were unable to turn it around before Pape Matar Sarr - set up by ex-Everton forward the Brazilian - headed home a final goal to seal the victory.
Jake O'Brien thought he had equalized the scores a short while after Van de Ven's opener, glancing a bullet header past the Spurs keeper from an set-piece.
The Portuguese striker, meanwhile, missed a handful of chances, while the Italian goalkeeper made a series of excellent stops to ensure the London club went five matches on the road without defeat in the Premier League.
But the video assistant referee stepped in, instructing Craig Pawson to check the goal on the pitchside monitor and the referee decided that the winger and Iliman Ndiaye were in offside positions and had impeded with the Tottenham goalkeeper.
This victory elevates the manager's team up to third in the division, a handful of points off local foes and leaders Arsenal.
The Merseyside club remain in 14th position and sit six points ahead of the relegation zone.
Tottenham analysis: The defender excels in role at both ends of the field
After a uninspiring midweek display in the European competition against the French side, where they mustered a mere attempts on target, the manager opted for the French striker up front instead of former Toffees player the Brazilian.
The new arrival was unable to influence the game before being replaced for the substitute after 60 minutes on the pitch, but it turns out he proved unnecessary in the end.
Defender Van de Ven transformed into an attacking force to be reckoned with.
Tottenham's first goal came from a cleverly executed set-piece play, with Rodrigo Bentancur directing the ball back across the face of goal for an free the defender to head home.
And Ven de Ven - stepping up as skipper in Cristian Romero's unavailability - notched his second in first-half stoppage time as he rose above the England keeper to head home.
The Dutchman was equally impressive in defence, partnering effectively with his defensive colleague as the duo dealt excellently with the numerous deliveries sent their way by Everton.
Toffees breakdown: Everton missing finishing touch
Everton's new home had been a fortress, but it appears the freshness may have worn off somewhat and supporters flocked to the gates after Sarr's final goal for Spurs.
The break in the team's unbeaten home run won't be a massive concern for the manager, but their attacking woes will be.
The forward and the other striker - the Toffees' two established strikers - had scored only a single goal between them before Sunday's outing.
And they were unable to contribute to that poor record on a damp and dreary evening on in Liverpool.
The striker's performance was summed up when he opted to bicycle-kick a clear chance from close range, despite having space and opportunity to reposition for a more conventional shot that would have challenged Vicario.
Barry, as well, was unable to influence the game after replacing the starter in the 65th minute.
It was not for a shortage of chance. The majority of the home side's attacks came through the winger and Ndiaye, who tirelessly whipped dangerous crosses into the Tottenham penalty area.
What next for both teams?
The Toffees: Moyes' men travel to the Stadium of Light in the Premier League on Monday, 3 November at 20:00 GMT.
Spurs: Spurs go to St James' Park on late October for their fourth-round League Cup tie against the Magpies.